Cell surface effects of adriamycin and carminomycin immobilized on cross-linked polyvinyl alcohol.

Molecular pharmacological differences between carminomycin and its analog, carminomycin-11-methyl ether, and adriamycin.

The effects of carminomycin and its 11-methyl ether analog were characterized and compared with those of Adriamycin in several systems both in vivo and in vitro. When comparing maximum effective doses, carminomycin was found to be ap proximately I 0to 20-fold more potent in vivo than was Adria mycin against mouse Li 210 leukemia, and the latter agent was approximately equipotent with carminomyc...

Response Surface Methodology for Investigating the Effects of Hydrolysis Reaction Parameters on Molecular Structure and Performance of Polyvinyl Alcohol as Primary Suspending Agent

This study presents the synthesis of polyvinyl acetate (PVAc) by solution polymerization and its partial hydrolysis to polyvinyl alcohol (PVA) using alkaline alcoholysis. The influence of the molar ratio of hydrolysis catalyst (NaOH) to PVAc and the time and temperature of the saponification reaction on the degree of hydrolysis and molecular weight of the PVA were investigated using response su...

Surface Adsorption of Polyethylene Glycol and Polyvinyl Alcohol with Variable Molecular Weights on Zinc Oxide Nanoparticles

Modification of Polyvinyl Alcohol via Atom Transfer Radical Polymerization for Targeted Drug Delivery Applications

In current study,a hydrogel based on biocompatible polymerwas prepared. The functionalization of polyvinyl alcohol (PVA)with epichlorohydrin(ECH) to produce epichlorohydrin-g-polyvinyl alcohol (PVA/ECH) as a suitable macroinitiator for atom transfer radical polymerization (ATRP) reaction was investigated.ThenN-vinyl pyrrolidone (NVP) waspolymerized on the surface of macroinitiatorin presence of...

Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues.

Male Sprague-Dawley rats were treated with carminomycin i.v. in doses ranging from 1 to 40 mg/kg. Within 1 hr after the administration of carminomycin, 20 mg/kg, nucleoli of cardiac and skeletal muscle cells were segregated, while nucleoli of liver parenchyma cells were unaffected. Three and one-half hr after drug administration, cardiac muscle nucleoli reverted to normal ultrastructure. Howeve...